TABLE 32-2
Relative Activity of Natural and Synthetic Corticosteroids
Relative Bioactivity
Steroid
Structure
Glucocorticoid
Mineralocorticoid
Natural
CH2OH
Cortisol
Corticosterone
11-Deoxycorticosterone
Aldosterone
Synthetic
Prednisolone
(A
1
-cortisol)
MĂ©thylprednisolone
(
6
cÂŁ-methylprednisolone)
c=o
See Figure 30-2
See Figure 30-2
See Figure 30-2
CH2OH
C:0
1 0 0
1 0 0
2 0
2 0 0
0
2 0 0 0
1 0
40,000
400
70
500
50
Dexamethasone
(9a-fluoro-6a-methylprednisolone)
CH2OH
I
c=o
OH
3000
0
CH2OH
c=o
A - OH
Fludrocortisone (9a-fludrocortisol)
HO
1000
40,000
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